first_imgIn the two months since it launched the “Save Paste” campaign, ailing Decatur, Georgia-based music magazine Paste has raised more than $250,000 from approximately 10,000 donations—enough to keep the magazine in business.“We’ve published two issues since the campaign began, sent a third to the printer and are seeing advertising pick up for the fall and expect to be around for a long time,” publisher Nick Purdy wrote in an e-mail to FOLIO:. The campaign officially closes this month, he said.In May, Paste said it was cash-strapped and in crisis as ad dollars declined dramatically. Through the first week, the campaign raised $166,000. At the time, Paste said it needed an additional $134,000—or a total $300,000—to “take care of bills that spiraled up during the ad slump.” Paste said it implemented several cost-cutting measures, including a 20 percent pay cut, leasing out office space and eliminating all “non-essential travel.”Paste hopes to reinstate salaries before the end of the year, Purdy said.In addition to the campaign, Purdy said Paste is talking with investors “who want to get involved and help accelerate our growth.”last_img read more

first_img Tech Industry 9:40 AT&T 5G network has some of the fastest speeds we’ve… Samsung, LG, Motorola: How soon can we expect 5G phones? Ericsson pledged last year to invest in the “accelerated build out of 5G” in the United States. Washington has banned Huawei, one of the major makers of 5G gear, from the US market, creating opportunity for other suppliers. Federal Communications Commission Chairman Ajit Pai applauded Ericsson’s announcement.”Building 5G equipment in the United States is good for our economy, good for the supply chain, and good for the rapid rollout of the next generation of wireless connectivity in the United States,” he said.Ericsson didn’t give a location for the factory but said it would employ about 100 people. The factory itself will make use of 5G technology for fast, responsive networking that will aid in automation in its warehouses and on its assembly line.The company didn’t immediately respond to a request for further comment.  Earlier this year, CNET got an early look at some tiny 5G antennas that Ericsson was experimenting with. This is a 5G small cell at Verizon’s 5G lab in Cambridge, Massachusetts. Jon Skillings/CNET Ericsson said Wednesday that it plans to open a factory next year in the US to build 5G gear as the next-generation wireless technology moves toward the mainstream. The factory will produce 5G radios, the element in phones and other devices that sends and receives the 5G signal, for use in urban areas. It also will make Advanced Antenna System radios that it said are components for large-scale deployments of 4G and 5G networks.5G, the next generation of cellular technology, offers faster speeds and lower latency between devices. Carriers like Verizon and AT&T in the US, Telstra in Australia and EE in Britain are just now starting to establish 5G mobile networks in a handful of big cities. Tags Now playing: Watch this: Share your voice 13 Photos Comment 1 5G AT&T Ericsson Verizonlast_img read more

first_imgDamage is seen at St. Sebastian Catholic Church, after bomb blasts ripped through churches and luxury hotels on Easter, in Negambo, Sri Lanka 22 April, 2019. Photo: ReutersAuthorities lifted a curfew in Sri Lanka on Monday, a day after a string of bombings at churches and luxury hotels across the Indian Ocean island killed 290 people and wounded about 500, but there were warnings more attacks were possible.There was still no claim of responsibility for the Easter Sunday attacks on two churches and four hotels in and around Colombo, the capital of predominantly Buddhist Sri Lanka, and a third church on the South Asian nation’s northeast coast.A government source said President Maithripala Sirisena, who was abroad when the attacks happened, had called a meeting of the National Security Council early on Monday. Prime minister Ranil Wickremesinghe would attend the meeting, the source said.Sri Lankan military who were clearing the route from Colombo airport late on Sunday in preparation for Sirisena’s return found a homemade bomb near the departure gate, an air force spokesman said.They disposed of the device in a controlled explosion, the spokesman said.There were fears the attacks could spark a renewal of communal violence, with police also reporting late on Sunday there had been a petrol bomb attack on a mosque in the northwest and arson attacks on two shops owned by Muslims in the west.Sri Lanka was at war for decades with Tamil separatists but extremist violence had been on the wane since the civil war ended 10 years ago.The South Asian nation of about 22 million people has Christian, Muslim and Hindu populations of between about eight and 12 per cent.The U.S. State Department issued a revised travel warning that said “terrorist groups” were continuing to plot possible attacks.”Terrorists may attack with little or no warning,” it said in the revised warning, which was dated Sunday U.S. time. The warning level was set at two on a scale where four means do not travel.Possible targets included tourist locations, transportation hubs, shopping malls, hotels, places of worship, airports and other public areas, it said.ARMED GUARDSThe island-wide curfew imposed by the government was lifted early on Monday, although there was uncharacteristically thin traffic in the normally bustling capital.Soldiers armed with automatic weapons stood guard outside major hotels and the World Trade Centre in the business district, where the four hotels were targeted on Sunday, according to a Reuters witness.Scores of people who were stranded overnight at the main airport began making their way home as restrictions were lifted.The government also blocked access to social media and messaging sites, including Facebook and WhatsApp, making information hard to gather.Wickremsinghe acknowledged on Sunday that the government had some prior information about possible attacks on churches involving a little-known Islamist group but said ministers had not been told.Sri Lankans accounted for the bulk of the 290 people killed and 500 wounded, although government officials said 32 foreigners were also killed. These included British, US, Turkish, Indian, Chinese, Danish, Dutch and Portuguese nationals.A British mother and son eating breakfast at the luxury Shangri-La hotel were among those killed, Britain’s The Telegraph newspaper reported.One Australian survivor, identified only as Sam, told Australia’s 3AW radio the hotel was a scene of “absolute carnage”.He said he and a travel partner were also having breakfast at the Shangri-La when two blasts went off. He said he had seen two men wearing backpacks seconds before the blasts.”There were people screaming and dead bodies all around,” he said. “Kids crying, kids on the ground, I don’t know if they were dead or not, just crazy.”There were similar scenes of carnage at two churches in or near Colombo, and a third church in the northeast town of Batticaloa, where worshippers had gathered for Easter Sunday services. Pictures from the scene showed bodies on the ground and blood-spattered pews and statues.Dozens were killed in one of the blasts at the Gothic-style St. Sebastian church in Katuwapitiya, north of Colombo. Police said they suspected that blast was a suicide attack.Three police officers were also killed when security forces raided a house in Colombo several hours after the attacks.Police reported an explosion at the house.last_img read more

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Journal information: Cell Reports Explore further (Phys.org)—Every organ strikes its own balance between self-renewal and differentiation. At one extreme is the brain, where only a few isolated outposts are known to contribute to a largely quiescent population. At another extreme are the testes, where at least in males, prolific germline turnover is maintained amidst a protracted and deliberate multi-month creation cycle. Perhaps surprisingly, both organs are uniquely immunoprivileged against various vascular indiscretions and yet rely on various myeloid-derived cells like macrophages or microglia to instruct important structural maturations. The so-called stem cell ‘niche’ is the microenvironment of the stem cell: all those physical and molecular intangibles that nourish, shield and inform its major life decisions. In creatures like worms and flies a well-defined stem cell niche is distally localized within a polarized gonad. By contrast, each testes of the mammal can contain up to 40,000 potential stem cell niches more-or-less randomly dispersed among its seminiferous tubules. A recent paper published in Cell Reports has removed some of the mystery in the mammalian reproductive system by showing that a unique class of testicular macrophages define its putative stem cell niche.Perhaps even more importantly, they also show that these macrophages control spermatogonial differentiation through the expression of critical factors including CSF1 (colony-stimulating factor) and retinoic acid synthesis enzymes. When the researchers ablated the macrophages by making them selectively and transiently susceptible to the diphtheria toxin, they found a drastic reduction in the number of spermatogonia. This new found responsibility of macrophages complements their previous known testicular functions in promoting steroidogenesis in Leydig cells. They are also known to be intimately involved in vascular development in several places, including the brain. We should mention that the immune barrier in the brain is due mainly to the endfeet of astroglial cells while in the testes it is created by tight junctions in the Sertoli cells that nurse the developing spermatogonia.The single spermatogonium is the most undifferentiated cell within the prevailing model of the spermatogonial stem cell hierarchy. In the fullness of time each one progresses through an incomplete cytokinesis, giving rise to syncytial cysts of spermatogonia progeny that are held together in formation by cytoplasmic bridges. In this way those cells in the syncytium that lack and X chromosome can still get copies for things like glucose 6 phosphate dehydrogenase. Similarly those cells that find themselves without a Y still have access to essentials like the RBM gene, which is critical later in spermatogenesis. Testes. Credit: smithlhhsb122.wikispaces.com More information: The New Director of “the Spermatogonial Niche”: Introducing the Peritubular Macrophage, Cell Reports, Volume 12, Issue 7, p1069–1070, 18 August 2015. dx.doi.org/10.1016/j.celrep.2015.07.057Macrophages Contribute to the Spermatogonial Niche in the Adult Testis, Cell Reports, Volume 12, Issue 7, p1107–1119, 18 August 2015. dx.doi.org/10.1016/j.celrep.2015.07.015 Mechanisms for continually producing sperm © 2015 Phys.org For most men, the only time they ever hear the word macrophage in reference to their testicles is when it comes time for the vasectomy. Upon being told during that actual sperm production is totally unaffected by a vasectomy, any reasonable man might be expected to wonder, perhaps aloud, ‘what happens to all the sperm’? Typically there is some mumbling about macrophages taking care of all that, although the actual details are a bit shoddy. This new evidence regarding the intimate relationship between macrophages, spermatogenesis, and perhaps even spermicide, points to the indebtedness we have to these dynamic cells.Since we have already broached the subject we might take the opportunity to share a few more illuminative details that may benefit anyone undergoing significant alterations to their reproductive plumbing. While a general attitude of ‘the less you know, the better’ may often prevail in such matters, there are some things a patient should probably know. In up to half of patients something known in the business simply as ‘epididymal blowout’ will occur. This is something every bit as horrid to imagine as it sounds. Typically, pressure in the vas deferens (which usually is tied off or electrocauterized) builds up over the course of several weeks post-op to the point that it ruptures, frequently accompanied by some pain and possible formation of epidydimal cysts. Fortunately, through a cooperative macrophage effort, this situation largely resolves on its own.However for some men something even more sinister lurks within. Another word that can bring even the strongest to their knees is ‘re-canalization’. This situation is also precisely as it sounds—complete regrowth and functional connection of a severed vas deferens. It is not yet known exactly how or when this can occur other than to say that ‘where there’s a will there’s a way’. For men lucky enough to avoid any of these potential pitfalls there is probably only one remaining concern: what happens to levels of testosterone?Studies have apparently shown that testosterone levels remain the same on average. What such a devilish statement hides is that depending on your particular constitution and sequalae, you might your own individual expect levels to change, either for the better or for worse. In other words, with evidence in literature for both increases and decreases, it is fair to say we need more research on how such things are ultimately controlled in the gonads. Citation: Macrophages create the elusive spermatogonial stem cell niche (2015, September 3) retrieved 18 August 2019 from https://phys.org/news/2015-09-macrophages-elusive-spermatogonial-stem-cell.htmllast_img read more