Up next for the Huskies is a road tilt against the North Peace Navigators. A win by the Huskies would give them a three point cushion on the Navs while keeping the pressure on the Grande Prairie JDA Kings. The contest can be heard live on Moose FM with the pregame show starting at 7:45, and the opening faceoff at 8 p.m. Head Coach Gary Alexander says that when you have games where the outcome is never in doubt, they provide a good opportunity to brush up on systems but it is hard to play like that throughout the entire contest.“It progressively gets to be more of a one man show out there as it goes along because everyone wants to get in on all of the points,” he explains. “They have a tendency to forget the fact that they got the points started by being a team. It’s not fun playing these games because a lot of concentration is lost as the game goes on.”Alexander says the team has been playing well lately but is well aware that stumbles will happen as the season progresses.- Advertisement -“We’re gaining every day I think. We’re bound to have a relapse sooner or later but you have to have a high and a low and we are hoping to ride a high through Peace River tomorrow,” he says. “If everybody sticks to what we’ve been doing in the last month we have a pretty good chance at going into Peace River and coming out with a win.”Scoring goals in order for the Huskies tonight were Cayle Bell, Dylan Houle, Jordan Gies, Cayle Bell, Pierce Layne, Brighton Campbell, Owen Barker, Owen Barker, Brighton Campbell, Cayle Bell, Dylan Houle, and Pierce Layne.Shots on the night were well in favour of Fort St. John 45-27. Getting the win in goal was Daimon Derouin.Advertisement
Some Cambridge scientists engineered a four-character genetic code and made some proteins with it. They guided the process at every step, but claim that they “evolved” this code. Is that a fair use of language? This strange admixture of concepts is found in today’s issue of Nature.1 The confusion began right in the title: “Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome.”…orthogonal pairs have been evolved to incorporate a range of unnatural amino acids…Here we synthetically evolve an orthogonal ribosome (ribo-Q1) that efficiently decodes a series of quadruplet codons….Because the synthetase�tRNA pairs used have been evolved to incorporate numerous unnatural amino acids it will be possible to encode more than 200 unnatural amino acid combinations using this approach.….this work provides foundational technologies for the encoded synthesis and synthetic evolution of unnatural polymers in cells.Natural ribosomes are very inefficient at, and unevolvable for quadruplet decoding, which would enhance misreading of the proteome.…orthogonal ribosomes … may, in principle, be evolved to efficiently decode quadruplet codons on the orthogonal message….To discover evolved orthogonal ribosomes that enhance quadruplet decoding we first created 11 saturation mutagenesis libraries in the 16S ribosomal RNA of ribo-X (an orthogonal ribosome previously evolved for efficient amber codon decoding on an orthogonal message)….We used ribo-X as a starting point for library generation because we hoped to discover evolved orthogonal ribosomes that gain the ability to efficiently decode quadruplet codons while maintaining the ability to efficiently decode amber codons on the orthogonal mRNA….To explicitly compare the fidelity of triplet decoding and quadruplet decoding for the evolved orthogonal ribosomes and the progenitor ribosome we used two independent methods….….which is derived from the … pair, by a series of generally applicable directed evolution steps….…it will be interesting to investigate the enhancement of protein function that may be accessed by combining the encoding of these cross-links with directed evolution methods.What’s notable in this paper was not only the flagrant use of evolve as an active method that the scientists used to investigate function for the purpose of enhancing protein synthesis, but also their use of the stem word “natural.” They spoke of unnatural amino acids (those not found in wild-type living cells), and described their attempts to achieve of “synthetic evolution of unnatural polymers in cells.” They spoke of the “inefficiency with which natural ribosomes decode quadruplet codons” but then praised their fidelity with their triplet system: “Natural ribosomes decode triplet codons with high fidelity (error frequencies ranging from 10-2 to 10-4 errors per codon have been reported).” Another mixing of unguided and designed concepts appears in their use of synthetic. They spoke of “synthetic evolution” (their lab work) but also used and altered the “natural” molecular machines that bind amino acids to transfer-RNA, the tRNA synthetases. Consider also how the concept of coding was used: they wished to achieve “synthetic genetic code expansion” They shifted seamlessly between the natural genetic code and their expanded, synthesized quadruplet code. With all this mixture of terms synthesizing and evolving natural and unnatural codes, the reader is left wondering what “evolved” on its own, if anything, and what was intelligently designed.1. Neuman, Wang, Davis, Garcia-Alai, Chin, “Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome,” Nature 464, 441-444 (18 March 2010); doi:10.1038/nature08817.Answer: everything was intelligently designed, both the natural and unnatural codes and functions. This paper was one of the best examples in recent memory of Truman’s Law: “If you can’t convince them, confuse them.” Using evolve as a synonym for design is a clever way to blow smoke using equivocation. Words mean things. This has nothing to do with evolution in the way Darwin used it, and in the way the debate rages today. It has everything to do with intelligently designing codes to synthesize things they would not naturally do (that is, without the intervention of a human mind). These human designers did not “evolve” anything, and they did not rule out intelligent design in the “natural” systems. If they really wanted to talk about evolution, they should have left the lab and let “nature” take its course. “Synthetic evolution” is as sophoxymoronic (02/02/2008 commentary) as holy atheism.(Visited 31 times, 1 visits today)FacebookTwitterPinterestSave分享0
Kelebogile Boikanyo and Aubrey Lodewyk play the parts of lovers Musetta the singer and Marcello the painter in Opera Africa’s production of La Bohème. (Image: Opera Africa) Sandra and Hein de Villiers’s passion for opera has led them to mortgage their house to fund a production – not once, but twice.Sandra is the CEO of Opera Africa, the company she started in 1994 “with the vision of fostering new audiences for opera that were previously excluded from enjoying this genre, and to promote talented young soloists and choristers”. Hein has been Opera Africa’s artistic director since 1995. Like his wife, he brought with him a distinguished track record from more than two decades in music education, as both teacher and administrator.Together with a band of similarly committed individuals – and, of course, some extremely talented performers, directors and visual artists – the pair have been the driving force behind staging a host of operas in South Africa over the last 15 years, including such favourites as Carmen, Faust, La Traviata and Aida.The name of the company is usefully ambiguous; inserting different prepositions between the words “Opera” and “Africa” gives you some idea of both its ambitions and successes. For starters, there is the slightly contentious question of opera in Africa – does a Eurocentric high-art form such as opera have a place in post-apartheid South Africa?Well, yes. First, there are musical and aesthetic strong affinities between opera and South Africa’s well-established choral tradition. Second, in an era of unprecedented globalisation and migration of cultures, there is little value in essentialising what it means to be “African” or “European”.A fine example of such hybridisation is, in fact, Opera Africa’s Princess Magogo – the first full opera sung entirely in isiZulu. First staged in 2000, this is an opera about Africa, depicting the life and times of one of the Usuthu-Buthelezi dynasty’s most famous daughters, herself a renowned composer and singer, with a score by Mzilikazi Khumalo and libretto by Themba Msimang.Princess Magogo and the company’s other productions have appeared across South Africa, in major urban centres as well as in more remote rural areas – opera for Africa, one might say. But they have also toured internationally, in cities as far afield as Chicago, Amsterdam and Oslo, demonstrating that there is such a thing as opera from Africa.Opera Africa’s latest enterprise is La Bohème, which will run at the State Theatre in Pretoria in March 2010 before moving to the Joburg Theatre Complex in Johannesburg in April. (The company has established a good working relationship with these two major Gauteng theatres since relocating from Durban six years ago.)La Bohème is, after Madama Butterfly, the most popular work by Italian composer Giacomo Puccini. Based on Henri Murger’s novel, Scenes from Bohemia, the opera is set in 19th-century Paris and centres on the love affair between Mimi, a seamstress, and Rodolfo, a poet.Over the course of its 110-year performance history, La Bohème has contributed substantially to the modern archetype of the poor artist, struggling in a freezing garret to create immortal works of art but also finding ways to indulge in bouts of hedonism. This archetype has had more recent manifestations in, for instance, the Broadway musical Rent or Baz Luhrman’s film Moulin Rouge.The themes of poverty and illness have obvious echoes in contemporary South African society. While previous Opera Africa productions have foregrounded such similarities by presenting “African” settings, however, the artistic team behind La Bohème have chosen not to do so here. Instead, the production will be “an exquisitely imagined period piece” taking for granted that the “universal and timeless themes” of Puccini’s opera will resonate with local audiences.Andrew Verster, who has worked with Opera Africa as set and costume designer on numerous occasions, will again weave his visual magic, and Themi Venturas, whose Opera Africa repertoire includes Princess Magogo and the 2007 Opera Extravaganza, will direct the stage action.Musically, the production promises to be of the highest standard. Conductor Timothy Myers, who has previously worked with orchestras in New York and London, will have the Johannesburg Philharmonic Orchestra under his baton. And the company has recruited a formidable group of divas and divos to give voice to the lead roles.Soprano Hanli Stapela, joining Opera Africa for the first time, brings an international reputation to her reprisal of Mimi’s tragic story. Tenor Stéfan Louw, who has likewise been widely acclaimed for his performances in previous productions of La Bohème, will portray the equally unfortunate Rodolfo.Two rising stars of the South African opera scene, Kelebogile Boikanyo and Aubrey Lodewyk – both products of the Tshwane University of Technology’s vocal arts programme – will sing the parts of Musetta and Marcello, the singer and painter whose tempestuous on-off relationship mirrors that of Mimi and Rodolfo. Otto Maidi completes a quintet of bohemian characters as Colline, the philosopher. Veteran bass Rouel Beukes will contribute his idiosyncratic combination of gravitas and levity to two roles: Benoit, Rodolfo’s landlord, and Alcindoro, the wealthy government minister who fancies Musetta.And it’s worth mentioning that the production is sponsored by the National Lottery Distribution Trust Fund – so Sandra and Hein won’t need to mortgage their house again.
Prime Minister Manmohan Singh.Prime Minister Manmohan Singh on Wednesday rejigged the Union cabinet, without disturbing the ‘big four’ incumbents in Finance, Home, Defence and External Affairs. This was the first cabinet reshuffle in the UPA-II after it retained power in May 2009. Praful Patel, Sriprakash Jaiswal and Salman Khursheed were elevated as cabinet ministers. While Urban Development Minister Jaipal Reddy has been shifted to Petroleum and Natural Gas, Kapil Sibal retains Telecom and HRD. Cabinet ministers:Praful Patel : Heavy Industries and Public EnterprisesShriprakash Jaiswal : CoalSalman Khursheed : Water Resources and additional charge of Minority AffairsMinister of State (Independent charge): Ajay Maken : Youth Affairs and SportsBeni Prasad Verma : SteelProfessor K. V. Thomas : Consumer Affairs, Food and Public DistributionMinisters of State:Ashwani Kumar : Planning and Parliamentary Affairs and Science and Technology and Earth SciencesK.C. Venugopal : PowerThe portfolios of the following Ministers have been changed:Cabinet ministers:Sharad Pawar : Agriculture and Food Processing IndustriesVirbhadra Singh : Micro, Small and Medium EnterprisesVilasrao Deshmukh : Rural Development and additional charge of Panchayati RajS. Jaipal Reddy : Petroleum and Natural GasKamal Nath : Urban DevelopmentVayalar Ravi : Overseas Indian Affairs and additional charge of Civil AviationMurli Deora : Corporate AffairsKapil Sibal : Human Resource Development and additional charge of Communications and Information TechnologyB.K. Handique : Development of North-Eastern RegionC.P. Joshi : Road Transport and HighwaysKumari Selja : Housing and Urban Poverty Alleviation and additional charge of CultureSubodh Kant Sahay : TourismDr. M.S. Gill : Statistics and Programme ImplementationPawan Kumar Bansal : Parliamentary Affairs and additional charge of Science and Technology and Earth SciencesMinister of State (Independent charge): advertisementShri Dinsha Patel : MinesMinisters of State: E. Ahamed : External AffairsHarish Rawat : Agriculture and Food Processing IndustriesV. Narayanasamy : Parliamentary Affairs and Personnel, Public Grievances and Pensions and Prime Minister’s OfficeGurudas Kamat : Home AffairsA. Sai Prathap : Heavy Industries and Public EnterprisesBharatsinh Solanki : RailwaysJitin Prasada : Road Transport and HighwaysMahadev S Khandela : Tribal AffairsR.P.N. Singh : Petroleum and Natural Gas and Corporate AffairsTusharbhai Chaudhary : Road Transport and HighwaysArun Yadav : Agriculture and Food Processing IndustriesPratik Prakashbapu Patil : Coal
A personalised map of what to pick, what to drop and what to envy.Restaurant reviewAll in one The new multi-cuisine restaurant, Omnia at Community Center, Saket is worth a try. There is Italian, Thai, Indian and Lebanese cuisine to choose from. But don’t expect an extensive menu. Their menu is a mix of famous dishes from all cuisines. “We wanted to offer as much as possible under one roof,” tells SM Malhotra, Executive Chef. The restaurant’s interior palette consists of black, white, beige and orange and the chairs are comfortable enough to make you sit for long hours. Must try: Garlic Chicken Fettuccinni, Chicken Roulette, Chicken in Green Curry.Meal for two: Rs 1,200 (including taxes)Adrenaline attackThe air of Underdoggs air is contagious. It makes you want to think, drink and eat sports. The latest sports bar and cafe in Ambience Mall, Vasant Kunj has all the perfect ingredients for a fun-filled evening. With 40 HDTVs and four projection screens, pool table, shuffleboards to dart boards and even table tennis, it is practically a sports complex. You can indulge in some ‘great American pub food’, along with a drinking game menu on custom tables with ping-pong balls or with cups, cards and dice. Must try: Jalepeno and Cheese Dynamites Meal for two: Rs1,550.In and outIf you are looking for a quick lunch, 1440, the 24 hour Lounge & Cafe in Hotel Vikram is your stop. The place offers good options for grub on the go, plus point being their 24X7 service. The menu is simple and uncomplicated with Indian and Oriental food. Their appetizers don’t do their job but the main course compensates for it. With hookah and foot-thumping numbers in the backdrop, their lounge is meant for the nocturnal breed. Drop in at midnight to experience the trance. Must try: Murgh lababdar with garlic naan, chilly chicken in bean sauce. Meal for two: Rs 1,000Things we loveadvertisementPint-sized pizza: Next time you go to Big Chill Cafe make sure you have a pint of beer with your favourite pizza as one of their outlets in Kailash Colony has got a liquor license.Retail therapy: Good news for all you shopaholics, its time to shop till you drop this summer. One of the most popular malls of the city, Select City walk has extended time to 11 p.m.Things we don’tInspiration or copy? It wasn’t too long ago when Delhi-based designer Manav Gangwani’s infamous black dress received flak for copying from an international designer. The latest to join the brigade is designer duo Gauri and Nainika. It’s time for more innovation than inspiration. What say, people?Sun baked: Hot is not hot. Think inflated AC bills, scorching auto rides and road rage. With soaring temperatures, the coming days promise to be difficult. Thinking of heading to Himalayas, already? Make do with ACs meanwhile.New productsSole comfortOzel introduces butterfly twists-clever little soles. They’re lightweight ballet pumps, which can be twisted and slipped into a neat little pouch. You can tuck in your bag to save your soles for a night out. So kick off your heels, and shimmy the night away. Price: Rs 1,250-Rs 1,500. Available at: M-7, G.K.-1 M-Block Market.Cinderella fitThese shoes, from the Indian luxury footwear brand Taramay are handmade with the highest quality fabric.Their first collection focuses on ballet flats with a ten-piece collection ranging from suede to tweed and lace. Price on request Available at: Ensemble.Wrist couture The 70’s inspired La D De Dior is a classic piece. With 227 diamonds, it will fit all wrists but not every wallet. Price: Rs 1,160,000 onwards. Available at: Johnson’s Watch Co.Bagilicious summer Are you looking for an instant boost to complement the season’s look? Fret not. Lavie is here with its brand new spring summer collection. Be it pastel shades or hot reds, your wardrobe is definitely incomplete without them. Price: Rs 1,700 onwards. Available at: Select City Walk.
Syed Mohammad Arif has nurtured some of the top badminton talents in the country, but Saina Nehwal was ‘special’. Now, his talented protegee has an Olympic medal to boast of.’Arif sir’, as he is fondly called in badminton circles, can vividly recall the 1998 summer camp in Hyderabad from where coach Nani Prasad Rao selected an eight-year-old from a bunch of 250-odd kids.”She was Saina and she was an average kid to start with. But as the days passed, I could make out that she was a cut above the rest,” Arif told Mail Today.”Saina was prepared to follow whatever she was told. She would never shy away from hard work and was always ready to push herself. She literally pushed her body to limits in the training. That is when I realised that she was a special talent and will go a long way.”Saina trained under Arif at the Lal Bahadur Shastri indoor stadium till the latter retired as coach from the Sports Authority of India. In 2005, Saina moved under Pullela Gopi Chand, who too has been trained by Arif.”At a young age, she used to compete in 4-5 events in age group tournaments and she would win. She was playing at the senior level when she was just 14,” he said.Arif also gives a peek into the sacrifices her family had to make. “She used to stay far off from the stadium and we would start at 5.30 in the morning. Her father or mother would bring her along and pick her up. To do that for years was not easy. The family has had to sacrifice a lot and I am happy for them today.”advertisementIt wasn’t just Arif, but the entire badminton fraternity that was waiting in anticipation for Saina to win a medal. “She has done us proud. We are extremely elated,” former Asian champion Dinesh Khanna told Mail Today.”She was the only non-Chinese player in the semis and it was not easy for her. She has played so well till the quarter-finals. She had an exceptional win against Tine Baun.”